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The Stroke Belt or Stroke Alley is a region in the southeastern United States that has been recognized by public health authorities for having an unusually high incidence of and other forms of cardiovascular disease. It is usually defined as a 11-state region consisting of , , Georgia, , , , , , , , and . It is often disputed if belongs in the Stroke Belt.Emily Ramshaw, East Texans’ Bad Health and Bad Habits Promote a ‘Stroke Belt’, The New York Times, January 14, 2011


Geographic scope
The Stroke Belt is typically defined to include the states of Alabama, Arkansas, Georgia, Indiana, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, and Virginia. In 1980, these 11 states had age-adjusted stroke more than 10% above the national average. Stroke Belt Initiative: Project Accomplishments and Lessons Learned , National Heart, Lung, and Blood Institute, National Institutes of Health; reports on a conference that occurred in 1996

Some investigators also consider to be a part of the Stroke Belt, based on a stroke mortality rate higher than several states included in the region. is also characterized as part of the Stroke Belt.


History of observations
The Stroke Belt was first identified in 1962 by Centers for Disease Control (CDC) researchers who noted a concentration of high stroke death rates in the counties of North Carolina, South Carolina, and Georgia. Combating Southern Fried Fat, CBS News, February 14, 2005 Similar high stroke rates were later observed in the Mississippi Delta region as well.

Analysis by the CDC of U.S. mortality statistics from 1991 to 1998 found that for both blacks and , counties with the highest stroke death rates were in the southeastern states and the Mississippi Delta region. Stroke death rates for states ranged from a high of 169 per 100,000 in South Carolina to a low of 89 per 100,000 in New York. CDC Releases Atlas of Stroke Mortality , Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention & Health Promotion, February 20, 2003 While most observational studies have focused primarily on stroke incidence in adults, in 2004 researchers reported that children in the eleven Stroke Belt states also have an increased risk of death from ischemic and hemorrhagic stroke compared with children in other states.

Glymour et al. (2007) reported that adults who had resided in the Stroke Belt during childhood and had moved outside the region had higher stroke risk at ages 50 and older than adults who grew up in areas with lower stroke incidence. A study reported in 2011 found that people over age 45 living in the eight "stroke belt" states of Alabama, Arkansas, Georgia, Louisiana, Mississippi, North Carolina, South Carolina, and Tennessee had an 18 percent higher incidence of cognitive decline than people in other U.S. regions. Another researcher noted that, "Stroke by itself is a major contributor to cognitive impairment and dementia."Mary Elizabeth Dallas, U.S. Southeast 'Stroke Belt' Also Shows Higher Rates of Cognitive Decline, Health Day (MedLine Plus), May 26, 2011 Other researchers have made similar observations.

In 2011, CDC researchers mapped the occurrence of in the U.S. by county, finding that highest prevalence of diabetes is in a "diabetes belt" that has extensive overlap with the Stroke Belt.


Hypotheses on causation
The causes of the elevated incidence of stroke in the Stroke Belt region have not been determined. Stroke Mystery, , November 8, 2005 Numerous possible contributing factors have been identified, including , low socioeconomic status, diet, cultural lifestyle, quality of healthcare facilities, , and . Among the specific factors that have been proposed or studied are the following:
  • It has been suggested that the higher stroke death rates in the Stroke Belt are due to the region's high African American population, because African Americans' stroke death rates are higher than the national average.African American males age 45 to 54 have a threefold greater risk of ischemic stroke than white males in the same age range.[7] However, because white people also have higher rates of stroke death in the Stroke Belt than in other parts of the country, the higher death rates in the Stroke Belt cannot be attributed solely to the region's higher proportion of African Americans.
  • In the early 1990s it was hypothesized that deficiency in the of the coastal plain might be a causative factor.Felicity Barringer, Toward Solving the Mystery Of the American 'Stroke Belt' , The New York Times, July 29, 1992 The subsequent recognition of high stroke incidence in areas with different soil characteristics led researchers to reject this hypothesis. Introduction , Atlas of Stroke Mortality: Racial, Ethnic, and Geographic Disparities in the United States (Casper ML, Barnett E, Williams GI Jr., Halverson JA, Braham VE, Greenlund KJ). Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention, 2003
  • and infection can increase the risk of stroke in a variety of ways, such as by encouraging the process of . Residents of the Stroke Belt have a higher incidence of than the general U.S. population, as well as higher levels of C-reactive protein, which is a sign of inflammation in the body.
  • Some observers have assumed that more stroke belt residents suffer from untreated hypertension. However, researchers have found that residents of the southern United States are as likely to be aware of hypertension and receiving treatment as residents of other U.S. regions.Lisa Nainggolan, Hypertension may not be the whole story in the Stroke Belt, Medscape Medical News, February 9, 2005 Additionally, researchers who documented the region's elevated incidence of pediatric stroke noted that "If the stroke belt is solely caused by regional differences in atherosclerotic stroke risk factors, it should not apply to children."
  • It has been suggested that one cause of higher mortality may be the predominantly rural character of the region, which increases the distances that patients must travel to obtain emergency medical treatment. Regional differences in standards of medical care have also been suggested as a contributing factor. In one study, researchers found that patients discharged from hospitals in the Stroke Belt after suffering acute myocardial infarction were less likely to be treated with than patients in most other U.S. regions. Stroke Belt — A Standard of Care Phenomenon?, Family Practice News, June 1, 2000
  • Glymour et al. (2007) suggested that the higher stroke incidence in the stroke belt is related to experiences or exposures in childhood.
  • It has been proposed that and in previous generations, which resulted in poor maternal and low birth weights, led to a predisposition to cardiovascular disease in adult life. Risk may be associated with mother's health , Health & Medicine Week, July 14, 2003
  • Diets high in and high- foods (such as or ), which are prevalent in the region, are thought to contribute to higher risk.
  • The same geographical area also has a higher than national average incidence of , as it is where much of the in the U.S. is grown. Smoking is reputed to be the strongest contributing factor of developing both diseases.
    (2025). 9780192625359, Oxford University Press. .


Public health initiatives to reduce stroke incidence in the region
The U.S. federal government has conducted programs specifically aimed at reducing stroke incidence and mortality in the Stroke Belt. In the 1990s the Stroke Belt Initiative operated in eleven Stroke Belt states, providing education, screening, smoking cessation programs, programs, and other health promotion and public education initiatives targeted at stroke risk factors.

In 2004, the Stroke Belt Elimination Initiative of the U.S. Department of Health and Human Services awarded grants aimed at reducing the high incidence of stroke and high rates of stroke death and disability in the seven states with the highest rates of stroke (Alabama, Arkansas, Georgia, Mississippi, North Carolina, South Carolina, and Tennessee).


Origins
The term "Stroke Belt" is modeled after similar terms used for U.S. regions such as "" and "", WordSpy website , posted on March 25, 2003 which extend the analogy to the belt as an article of clothing. The counties of the Carolinas and Georgia — where the stroke belt phenomenon was first described, and where stroke incidence is highest — are sometimes called the " of the stroke belt" or the "stroke buckle".


See also


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